- Noble Drew Ali (1886-1929) founder of Moorish Science Temple of America
- Drew (webcomic artist) (born 1979), artist of webcomic Toothpaste for Dinner
- Drew Barrymore (born 1975), US Actress
- Drew Bledsoe (born 1972), American Sportsman
- Drew Brees (born 1979), American Sportsman
- Drew Carey (born 1958), US Comedian
- Drew Henry (born 1968), Scottish Sportsman
- Drew Stanton (born 1984) US Sportsman
- Dr. David Drew Pinsky, known as Drew Pinsky or Dr Drew, (born 1958), US Medical expert and talkshow host
- Drew Leitch,Known as [Andrew Leitch] (born 1993) [Citizen of town Paisley]
B. Alvin Drew (born 1962), astronaut
- Bryce Drew (born 1974), US sportsman
- Cameron Drew
- Dr Charles R. Drew, (1904 - 1950), American physician and medical researcher
- Daniel Drew, 19th century railroad magnate and founder of Drew University
- David Drew, (born 1952), British Politician
- Dennis Drew
- Ellen Drew
- Frank Drew
- George Alexander Drew (Liberal-Conservative MP) (born 1826), Canadian Politician (Grandfather of George A. Drew)
- George A. Drew (1894?1973) Canadian Politician
- George Franklin Drew (born 1827) US Politician
- Georgiana Drew
- Gerald A. Drew
- Harold Drew, US Sports Coach
- Homer Drew
- Ira W. Drew, US Congressman from Pennsylvania
- Irving W. Drew (1845 - 1922), US Politician
- David Jonathan Drew, known as J. D. Drew (born 1975), US Sportsman
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- Jeff Van Drew
- Jessica Drew, fictional character, also known as Spider-Woman
- John Drew (actor) (1827 - 1862)
- John Drew Jr. (1853?1927), American actor
- John Drew (basketball)
- Kara Drew
- Kenny Drew (1928?1993) American musician
- Kenny Drew, Jr.
- Kevin Drew
- Larry Drew (born 1958), American Sportsman
- Linzi Drew
- Louisa Lane Drew
- Maurice Drew
- Michael Drew
- Nancy Drew, fictional teen sleuth
- Richard Drew (photographer)
- Richard Gurley Drew (1899 ? 1980), American inventor]
- R. Harmon Drew, Sr. (1917 - 1995) American Judge and Politician
- Robert Drew
- Ronnie Drew
- Ronnie Le Drew
- Samuel Drew
- Sarah Drew
- Scott Drew
- Stephen Drew (born 1983), US Sportsman
- Thomas Stevenson Drew (1802 - 1879), American Politician
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